Team 3
Biology and Physiopathology of the Spinal Cord

Understanding spinal cord function and repair across scales

Our team focuses on the biology and physiopathology of the spinal cord, as well as the peripheral nervous system. Our research strategy is built around four main axes:

  • Modulation of excitability and inflammation in Amyotrophic Lateral Sclerosis (ALS),
  • The role of neuromuscular junctions in motoneuron degeneration,
  • The effects of magnetic stimulation on regeneration and repair following Spinal Cord Injury (SCI) and in ALS,
  • The effects of electrical stimulation on the growth and guidance of peripheral nerves after complete injury and axonal outgrowth in vitro.

These projects combine in vitro and in vivo approaches, utilizing cutting-edge methods such as in vivo electrophysiology, chemogenetics, single-nucleus RNA sequencing, advanced imaging, and electroactive biomaterials. As a cross-cutting innovative approach, we are developing a scalable, non-invasive method for continuous 24/7 monitoring of motor activity in mice.

Our overarching goal is to generate fundamental insights with strong translational
potential for incurable diseases such as ALS, peripheral nerve injuries, and SCI.

Research areas : Spinal cord injury – Amyotrophic lateral sclerosis (ALS) – Neural plasticity – Glial cells – Motor neuron physiology – Neuromodulation

Research Topics

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Magnetic Stimulation for Spinal Cord Injury and ALS

Harnessing non-invasive magnetic stimulation to reduce inflammation and promote repair in spinal cord injury and ALS.

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Neuromuscular Junction Dynamics in ALS

Understanding how early neuromuscular alterations drive motor neuron degeneration in ALS.
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Drug Screening Approaches

Identifying and validating new therapeutic strategies for neurodevelopmental disorders.

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