Team 3
Biology and Physiopathology of the Spinal Cord
Understanding spinal cord function and repair across scales
Our team investigates the biology and pathophysiology of the spinal cord, from the neuromuscular junction to spinal motor circuits.
We study the mechanisms underlying neurodegeneration and neural plasticity, with a particular focus on motor neuron function and excitability

Our research also explores strategies to promote neural repair after injury, including the modulation of the spinal microenvironment and the enhancement of neurite growth.
Building on recent work, we are developing new research directions focusing on the role of glial cells in spinal cord injury and amyotrophic lateral sclerosis (ALS).
Located within a highly collaborative environment, we combine expertise in electrophysiology, advanced imaging, and behavioral analysis to better understand spinal cord function and recovery.
Research areas : Spinal cord injury – Amyotrophic lateral sclerosis (ALS) – Neural plasticity – Glial cells – Motor neuron physiology – Neuromodulation
Research Topics
Spinal motoneuron excitability is homeostatically regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice.
Antonucci S, et al.
Progress in Neurobiology | 2026
Motoneurons Inhibitory Synapses Homeostatically Respond to Neuronal Activity and Modulate Amyotrophic Lateral Sclerosis Pathogenesis.
Halablab K, et al.
The Journal of Neuroscience | 2026
Repetitive Trans-spinal magnetic stimulation Promotes Repair in Inflammatory Spinal Cord Injury Through Sex-Dependent Immune Modulation
Semprez F, et al.
The Journal of Neuroinflammation | 2026
Prolonged Repetitive Trans-Spinal Magnetic Stimulation Promotes Superior Functional Recovery After Severe Spinal Cord Injury in Rats
Garrido E, et al.
The Journal of Neurotrauma | 2026
Decoding Wetting Behavior: Capillary Rise Experiments with Amphiphilic Compounds and Theoretical Aspects
Hamraoui A, et al.
Langmuir | 2025
Spinal cord injury alters the therapeutic potential of olfactory ensheathing cells harvested in an autologous transplantation model
Delarue Q, et al.
Stem Cell Research & Therapy | 2025
The alpha7 nicotinic acetylcholine receptor mediates network dysfunction in a mouse model of local amyloid pathology
Koukouli F, et al.
Molecular Psychiatry | 2025
Renshaw cells, corelease and nicotinic receptors: The last journey in synaptic transmission
Lamotte d’Incamps B
Neuroscience | 2025
Involvement of the Endothelial N-Methyl-D-Aspartate Receptor on Vessel-Associated Positioning and Differentiation of Cortical Oligodendrocytes and on Motor Activity
Beranger A, et al.
The Journal of Neuroscience | 2025
KCC2 enhancers normalize reflex responses and improve locomotor function after chronic spinal cord injury
Bilchak JN, et al.
The Journal of Physiology | 2025
Team leader
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