Team 4
Membrane Dynamics
Decoding how membrane dynamics sustain cellular and synaptic homeostasis
Our team investigates how membrane trafficking and membrane transport processes regulate the maintenance and adaptive homeostasis of mammalian cells, with a particular focus on neurons and synapses.
Our research focuses in particular on the role of specific subcellular compartments, including the lysosome and the dendritic spine.
Located within a highly collaborative environment, we combine expertise in electrophysiology, advanced imaging, and behavioral analysis to better understand spinal cord function and recovery.
Research areas : 6 keywords
Research Topics
Recent Publications
Articles
- Molecular basis of Salla Disease: R39C Mutation Effects on the Lysosomal Transporter Sialin
Christos Matsingos, Isaure Lot, Malaury Vaz, Jade Mailliart, Meryam Boulayat, Cécile Debacker, Anne Goupil-Lamy, Bruno Gasnier, Francine C Acher, Christine Anne : (preprint), 2026 - Longitudinal brain ageing after stroke: a marker for neurodegeneration and its relevance for upper limb motor outcome.
Takyi RB, Plantin J, Charron S, Maier MA, Baron JC, Turc G, Rosso C, Debacker C, Lindberg PG : Brain Commun, 2025 - Roles of lysosomal small-molecule transporters in metabolism and signaling.
Damme M, Guelle O, Löw C, Gasnier B : Trends Cell Biol, 2025 - Elucidating the Activation Mechanism of the Proton-sensing GPR68 Receptor.
Matsingos C, Howell LA, McCormick PJ, Fornili A : J Mol Biol, 2024 - MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes
Katharina Esther Julia Jungnickel, Océane Guelle, Miharu Iguchi, Wentao Dong, Vadim Kotov, Florian Gabriel, Cécile Debacker, Julien Dairou, Isabelle McCort-Tranchepain, Nouf N Laqtom, Sze Ham Chan, Akika Ejima, Kenji Sato, David Massa López, Paul Saftig, Ahmad Reza Mehdipour, Monther Abu-Remaileh, Bruno Gasnier, Christian Löw, Markus Damm : Nature Cell Biology, 2024 - Novel Inhibitory Site Revealed by XAP044 Mode of Action on the Metabotropic Glutamate 7 Receptor Venus Flytrap Domain.
Cristiano N, Cabayé A, Brabet I, Glatthar R, Tora A, Goudet C, Bertrand HO, Goupil-Lamy A, Flor PJ, Pin JP, McCort-Tranchepain I, Acher FC : J Med Chem, 2024 - Epitope Identification of an mGlu5 Receptor Nanobody Using Physics-Based Molecular Modeling and Deep Learning Techniques.
Eshak F, Pion L, Scholler P, Nevoltris D, Chames P, Rondard P, Pin JP, Acher FC, Goupil-Lamy A : J Chem Inf Model, 2024 - Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)-2-((S)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu(2) Receptor Agonist.
Liu N, Eshak F, Malhaire F, Brabet I, Prézeau L, Renard E, Pin JP, Acher FC, Staudt M, Bunch L : J Med Chem, 2024 - Journaling as an effective tool to promote metacognition and enhance study methods in a pharmacology course, during and after the pandemic
Pena-Silva R A, Velasco-Castro J M, Matsingos C, Jaramillo-Rincon S X : The FASEB Journal, 2022 - Enzyme replacement therapy: current challenges and drug delivery prospects via extracellular vesicles
Silva A K, Sagné C, Gazeau F, Abasolo I : Rare Disease and Orphan Drugs Journal, 2022
