Team 1
Biophysics of the Brain
Decoding how glial cells shape brain function and synaptic communication
Our team investigates the contribution of glial cells, in particular cortical astrocytes and Bergmann glia of the cerebellum, to brain metabolism and signaling.
We study the mechanisms by which ion channels, transporters, and organelles in perisynaptic glial processes regulate and shape synaptic transmission.
Our research also explores astrocyte calcium signaling and its role in neuron–glia communication.
Building on recent work, we are developing new research directions focused on tissue clarification and advanced light-sheet imaging approaches.
We combine expertise in electrophysiology, advanced microscopy (including super-resolution, 3-D imaging, and linear and non-linear techniques), immunofluorescence, and mouse genetics to investigate glial structure and function across multiple biological models.
Research areas : Glial biology – Astrocyte signaling – Synaptic modulation – Calcium dynamics – Neuroglia interactions – Advanced imaging
Research Topics
Recent Publications
Journal articles
2026
- Marwa Moulzir, Doriane Hazart, Brigitte Delhomme, Martin Oheim, Clément Ricard. Label-free high-resolution volume imaging of cleared testes. Reproduction [Cambridge], 2026, ⟨10.1093/reprod/xaaf021⟩. ⟨hal-05468462⟩
- Marwa Moulzir, Doriane Hazart, Brigitte Delhomme, Martin Oheim, Clément Ricard. Light as a feather: A novel approach for whole- feather microstructure imaging through tissue clearing and autofluorescence imaging. Annals of Anatomy, 2026, pp.152781. ⟨10.1016/j.aanat.2026.152781⟩. ⟨hal-05471200⟩
2025
- Ilya Olevsko, Maria Shehadeh, Lakshmanan Eswaran, Dmytro Ohorodniichuk, Eti Teblum, et al.. Modular Hydrogel‐Based Nano‐Bead Emitters for Bright, Homogeneous Fluorescent Thin Films and 3D Architectures. Advanced Optical Materials, 2025, pp.e02454. ⟨10.1002/adom.202502454⟩. ⟨hal-05235666⟩
- Omer Shavit, Hervé Suaudeau, Carine Julien, Hodaya Klimovsky, Natalia Mañas-Chavernas, et al.. Combinatorial sample- and back-focal-plane imaging. Pt. I: Instrument and acquisition parameters affecting BFP images and their analysis. Biophysical Journal, 2025, 0, ⟨10.1016/j.bpj.2025.08.009⟩. ⟨hal-05236016⟩
- Clément Ricard, Doriane Hazart, Brigitte Delhomme, Marwa Moulzir, Irina Rakotoson, et al.. Fast Tissue Clearing and Volume Imaging Techniques for Anatomy. Microscopy Research and Technique, 2025, ⟨10.1002/jemt.70013⟩. ⟨hal-05236179⟩
- Doriane Hazart, Marwa Moulzir, Brigitte Delhomme, Martin Oheim, Clément Ricard. Imaging the enteric nervous system. Frontiers in Neuroanatomy, 2025, 19, pp.1532900. ⟨10.3389/fnana.2025.1532900⟩. ⟨hal-05236146⟩
- Abdullah Ahmed, Nuria Alegret, Bethany Almeida, Ramón Alvarez-Puebla, Anne Andrews, et al.. Interfacing with the Brain: How Nanotechnology Can Contribute. ACS Nano, 2025, 19 (11), pp.10630-10717. ⟨10.1021/acsnano.4c10525⟩. ⟨hal-05413699⟩
- Kaitlin Szederkenyi, Liliana Attisano, Martin Oheim, Christopher Yip. BPS2025 – Human astrocyte calcium signaling in a cerebral organoid. Biophysical Journal, 2025, 124 (3), pp.514a. ⟨10.1016/j.bpj.2024.11.2701⟩. ⟨hal-05413967⟩
- A. Singer, F. Trigo, L. Vinel, O. Gruere, I. Llano, et al.. A first morphological and electrophysiological characterization of Fañanas cells of the mouse cerebellum. The Journal of Physiology, 2025, 603 (4), pp.855-871. ⟨10.1113/jp285949⟩. ⟨hal-04803395v2⟩
Pre-publications
2025
- Kaitlin Szederkenyi, Aaron Au, Liliana Attisano, Martin Oheim, Christopher Yip. Morphological heterogeneity of human astrocytes in cerebral organoids. 2025. ⟨hal-05413987⟩
Team leader
