Team 1
Biophysics of the Brain

Team description

Decoding how glial cells shape brain function and synaptic communication

Our team investigates the contribution of glial cells, in particular cortical astrocytes and Bergmann glia of the cerebellum, to brain metabolism and signaling.
We study the mechanisms by which ion channels, transporters, and organelles in perisynaptic glial processes regulate and shape synaptic transmission.

Our research also explores astrocyte calcium signaling and its role in neuron–glia communication.
Building on recent work, we are developing new research directions focused on tissue clarification and advanced light-sheet imaging approaches.

We combine expertise in electrophysiology, advanced microscopy (including super-resolution, 3-D imaging, and linear and non-linear techniques), immunofluorescence, and mouse genetics to investigate glial structure and function across multiple biological models.

Research areas : Glial biology – Astrocyte signaling – Synaptic modulation – Calcium dynamics – Neuroglia interactions – Advanced imaging

Research Topics

Team photo

Optimization of MeCP2 Gene Replacement Therapy for Rett Syndrome

Improving gene therapy for Rett syndrome by enhancing brain delivery and fine-tuning MeCP2 regulation.

Team photo

Deciphering the Roles of Importins in CNS and PNS Functions

Exploring how nuclear transport proteins regulate neuronal function, behavior, and gene expression.

Team photo

Drug Screening Approaches

Identifying and validating new therapeutic strategies for neurodevelopmental disorders.

Recent Publications

Journal articles

2026

Marwa Moulzir, Doriane Hazart, Brigitte Delhomme, Martin Oheim, Clément Ricard. Label-free high-resolution volume imaging of cleared testes. Reproduction [Cambridge], 2026, ⟨10.1093/reprod/xaaf021⟩. ⟨hal-05468462⟩
Marwa Moulzir, Doriane Hazart, Brigitte Delhomme, Martin Oheim, Clément Ricard. Light as a feather: A novel approach for whole- feather microstructure imaging through tissue clearing and autofluorescence imaging. Annals of Anatomy, 2026, pp.152781. ⟨10.1016/j.aanat.2026.152781⟩. ⟨hal-05471200⟩

2025

Ilya Olevsko, Maria Shehadeh, Lakshmanan Eswaran, Dmytro Ohorodniichuk, Eti Teblum, et al.. Modular Hydrogel‐Based Nano‐Bead Emitters for Bright, Homogeneous Fluorescent Thin Films and 3D Architectures. Advanced Optical Materials, 2025, pp.e02454. ⟨10.1002/adom.202502454⟩. ⟨hal-05235666⟩
Omer Shavit, Hervé Suaudeau, Carine Julien, Hodaya Klimovsky, Natalia Mañas-Chavernas, et al.. Combinatorial sample- and back-focal-plane imaging. Pt. I: Instrument and acquisition parameters affecting BFP images and their analysis. Biophysical Journal, 2025, 0, ⟨10.1016/j.bpj.2025.08.009⟩. ⟨hal-05236016⟩
Clément Ricard, Doriane Hazart, Brigitte Delhomme, Marwa Moulzir, Irina Rakotoson, et al.. Fast Tissue Clearing and Volume Imaging Techniques for Anatomy. Microscopy Research and Technique, 2025, ⟨10.1002/jemt.70013⟩. ⟨hal-05236179⟩ PDF
Doriane Hazart, Marwa Moulzir, Brigitte Delhomme, Martin Oheim, Clément Ricard. Imaging the enteric nervous system. Frontiers in Neuroanatomy, 2025, 19, pp.1532900. ⟨10.3389/fnana.2025.1532900⟩. ⟨hal-05236146⟩ PDF
Abdullah Ahmed, Nuria Alegret, Bethany Almeida, Ramón Alvarez-Puebla, Anne Andrews, et al.. Interfacing with the Brain: How Nanotechnology Can Contribute. ACS Nano, 2025, 19 (11), pp.10630-10717. ⟨10.1021/acsnano.4c10525⟩. ⟨hal-05413699⟩
Kaitlin Szederkenyi, Liliana Attisano, Martin Oheim, Christopher Yip. BPS2025 – Human astrocyte calcium signaling in a cerebral organoid. Biophysical Journal, 2025, 124 (3), pp.514a. ⟨10.1016/j.bpj.2024.11.2701⟩. ⟨hal-05413967⟩
A. Singer, F. Trigo, L. Vinel, O. Gruere, I. Llano, et al.. A first morphological and electrophysiological characterization of Fañanas cells of the mouse cerebellum. The Journal of Physiology, 2025, 603 (4), pp.855-871. ⟨10.1113/jp285949⟩. ⟨hal-04803395v2⟩ PDF

Pre-publications

2025

Kaitlin Szederkenyi, Aaron Au, Liliana Attisano, Martin Oheim, Christopher Yip. Morphological heterogeneity of human astrocytes in cerebral organoids. 2025. ⟨hal-05413987⟩

Spinal motoneuron excitability is homeostatically regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice.

Antonucci S, et al.

Progress in Neurobiology | 2026

Motoneurons Inhibitory Synapses Homeostatically Respond to Neuronal Activity and Modulate Amyotrophic Lateral Sclerosis Pathogenesis.

Halablab K, et al.

The Journal of Neuroscience | 2026

Repetitive Trans-spinal magnetic stimulation Promotes Repair in Inflammatory Spinal Cord Injury Through Sex-Dependent Immune Modulation

Semprez F, et al.

The Journal of Neuroinflammation | 2026

Prolonged Repetitive Trans-Spinal Magnetic Stimulation Promotes Superior Functional Recovery After Severe Spinal Cord Injury in Rats

Garrido E, et al.

The Journal of Neurotrauma | 2026

Decoding Wetting Behavior: Capillary Rise Experiments with Amphiphilic Compounds and Theoretical Aspects

Hamraoui A, et al.

Langmuir | 2025

Spinal cord injury alters the therapeutic potential of olfactory ensheathing cells harvested in an autologous transplantation model

Delarue Q, et al.

Stem Cell Research & Therapy | 2025

The alpha7 nicotinic acetylcholine receptor mediates network dysfunction in a mouse model of local amyloid pathology

Koukouli F, et al.

Molecular Psychiatry | 2025

Renshaw cells, corelease and nicotinic receptors: The last journey in synaptic transmission

Lamotte d’Incamps B

Neuroscience | 2025

Involvement of the Endothelial N-Methyl-D-Aspartate Receptor on Vessel-Associated Positioning and Differentiation of Cortical Oligodendrocytes and on Motor Activity

Beranger A, et al.

The Journal of Neuroscience | 2025

KCC2 enhancers normalize reflex responses and improve locomotor function after chronic spinal cord injury

Bilchak JN, et al.

The Journal of Physiology | 2025
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