Team 3
Biology and Physiopathology of the Spinal Cord

The effects of magnetic stimulation on regeneration and repair following spinal cord injury (SCI) and in ALS

Spinal cord (SC) function can be impaired by trauma (SCI), inflammatory, or neurodegenerative diseases, which share common mechanisms including inflammation, demyelination, and neuronal loss, leading to motor and sensory deficits. These conditions can be modelled in mice using trauma, inflammatory, or transgenic approaches.

Our team focuses on spinal cord pathologies and on developing non-invasive therapies to modulate the deleterious environment. We have shown that repetitive trans-spinal magnetic stimulation (rTSMS) reduces inflammation and promotes myelin and neuronal preservation in a traumatic model.

Based on these results, we aim to further investigate the therapeutic potential of rTSMS in different models of spinal cord pathology, including trauma, inflammatory demyelination, and neurodegenerative diseases such as amyotrophic lateral sclerosis, while also exploring its underlying mechanisms.