Team 7
Molecular biology of
neuronal transport

In Silico and Preclinical Drug Screening for Neurodevelopmental Disorders

Building on our previous work, we use RNA-seq and in silico approaches to screen for drugs with new therapeutic properties, such as anxiolytics or painkillers, in models of neurodevelopmental disorders.

Rett syndrome remains an incurable pathology, and available treatments have long aimed only at alleviating symptoms. Building on targets identified in RTT mouse models, we collaborate with experts in medicinal chemistry and pharmacology to synthesise, characterise, and validate the therapeutic potential of new candidate drugs, with the goal of improving anxiety, pain, and comorbidities in these disorders.